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Microbiome Changes Linked To Artificial Sweeteners

Jason Phillippe by Jason Phillippe
January 5, 2024
in Nutrition
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Microbiome Changes Linked To Artificial Sweeteners

Photo by julien Tromeur on Unsplash

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Gut health is very important.

In a recent study, researchers investigated the impact of artificial sweeteners on the gut microbiome, revealing potential concerns regarding their effects. The study observed distinct differences in the gut bacteria of individuals who used sweeteners like aspartame (Equal), sucralose (Splenda), saccharin (Sweet’N Low), or stevia leaf extract compared to those who did not consume these sugar substitutes. Those who used artificial sweeteners displayed reduced diversity in their gut bacteria colonies within the small intestine or higher levels of bacteria known for producing harmful toxins.

Dr. Ruchi Mathur, the study’s lead author and an endocrinologist at Cedars-Sinai Medical Center, emphasized the potential adverse impact of artificial sweeteners on the gut microbiome. Despite the prevalence of over 140 million Americans using these substitutes to cut down on sugar intake, concerns persist regarding their efficacy in long-term weight management and potential associations with health issues like type 2 diabetes and heart disease.

The investigation specifically delved into the microbial composition of the small intestines in users of artificial sweeteners, comparing individuals using various sweeteners, including aspartame, against a control group that did not consume any artificial sweeteners. Surprisingly, those using sugar substitutes other than aspartame exhibited reduced bacterial diversity in the small bowel compared to the control group. However, individuals using aspartame showed similar bacterial diversity levels to the control group.

However, this similarity didn’t suggest positive outcomes for aspartame users. Their microbiomes displayed a tendency to produce cylindrospermopsin, a toxin associated with adverse effects on the liver and nervous system and considered a potential carcinogen.

Researchers underscored the necessity for further investigations to comprehensively understand how these observed alterations in gut bacteria due to artificial sweeteners might impact overall health. Gaining deeper insights into these effects remains crucial for a comprehensive assessment of the potential risks associated with the consumption of artificial sweeteners.

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