This is a breakthrough discovery.
A recent study has identified a genetic mutation linked to accelerated reproductive aging and increased miscarriage risk in younger women. The gene, KIF18A, has been found to hasten the aging process of a woman’s eggs, thereby reducing fertility, according to researchers.
Karen Schindler, a genetics professor at Rutgers University, highlighted the significance of the findings, stating that understanding the genetic factors contributing to egg abnormalities has been a challenge. She emphasized that this research marks a major advancement in identifying a specific genetic variant that plays a causal role in reproductive challenges.
Egg quality is crucial for successful reproduction, as abnormalities in egg chromosomes are a leading cause of miscarriages. These risks tend to increase with age. The study analyzed DNA sequences from women undergoing in vitro fertilization, searching for genetic patterns linked to poor fertility. Researchers discovered a genetic variant associated with the production of a higher number of abnormal eggs, which was validated in lab experiments. Mice engineered to carry this genetic variant also produced abnormal eggs earlier than normal, confirming a direct causal link.
Leelabati Biswas, a researcher in Rutgers University’s MD-PhD program, explained that these findings go beyond correlation and offer strong evidence of causation. The team plans to expand their research to identify more genetic factors that contribute to infertility, with the goal of developing precision medicine approaches for women.
This research holds promise for women seeking to better understand their reproductive health. Genetic testing could one day provide insights into miscarriage risks, enabling women to make informed decisions about when to have children or to freeze eggs while they are younger. Schindler noted that knowing one’s genetic risk could significantly improve reproductive outcomes, offering a personalized approach to family planning.
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