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Weight-Loss Treatments Show Remarkable Impact On Blood Pressure

Jason Phillippe by Jason Phillippe
February 8, 2024
in Weight Loss
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Weight-Loss Treatments Show Remarkable Impact On Blood Pressure

Photo by Volodymyr Hryshchenko on Unsplash

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This is killing two birds with one stone.

Two recent studies have unveiled compelling evidence of a notable decrease in blood pressure among adults undergoing specific weight-loss interventions. In one study, individuals receiving weekly injections of the drug tirzepatide experienced a significant reduction in blood pressure, while another study revealed that participants who underwent bariatric surgery exhibited enhanced blood pressure control after a five-year period compared to those solely relying on blood pressure medications.

According to Dr. Harlan Krumholz, a cardiologist at Yale University, these findings collectively underscore the pivotal role of effectively managing obesity in enhancing overall heart health. While the correlation between obesity and various health conditions such as high blood pressure and diabetes is well-established, the availability of effective treatments for obesity has been limited until now.

“This marks a new era,” Krumholz remarked. “While the understanding of this relationship is not new, we now possess the tools – including anti-obesity medications and surgery – that can yield profound benefits.”

The initial study, published in the American Heart Association journal Hypertension, revealed that tirzepatide significantly reduced blood pressure in adults with overweight or obesity over a nine-month period. Tirzepatide, marketed under the brand names Zepbound for obesity and Mounjaro for diabetes, had previously demonstrated substantial weight loss benefits in a larger clinical trial, leading to its approval by the US Food and Drug Administration for chronic weight management in November.

The study, funded by Eli Lilly, enrolled 600 adults with a body mass index (BMI) of 27 or higher who did not have type 2 diabetes and had either normal or controlled high blood pressure. Participants underwent blood pressure monitoring before and after nine months of weekly tirzepatide injections, revealing a significant decrease in systolic blood pressure, a crucial indicator of heart disease risk.

Dr. Michael E. Hall, chair of the Department of Medicine at the University of Mississippi Medical Center, noted that the observed reduction in blood pressure may be even more substantial, considering that many participants did not have high blood pressure initially.

Tirzepatide functions by mimicking the action of two gut hormones, stimulating insulin production to lower blood sugar levels and delaying stomach emptying to promote feelings of fullness. While its mechanism is akin to semaglutide, the active compound in the weight loss drug Wegovy, further studies are required to ascertain tirzepatide’s impact on cardiovascular conditions like heart attack and heart failure.

Overall, these findings are promising, indicating that novel weight-loss medications not only aid in reducing body weight but also improve various cardiometabolic complications associated with obesity, including hypertension and diabetes. However, additional research is necessary to elucidate tirzepatide’s long-term effects on blood pressure and cardiovascular health.

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