Slow down aging.
New research suggests that regularly taking omega-3 and vitamin D supplements can support health and slow down aging-related processes. In a study published in Nature Aging, researchers found that these supplements, when taken over three years, reduced biological aging by three to four months. The effect was even stronger when combined with regular exercise. Biological aging refers to the molecular changes in the body, meaning people of the same age can age at different rates based on their health. While the reduction in aging might seem small, the researchers believe this could have significant public health benefits, including a lower risk of age-related conditions.
The study analyzed data from the DO-HEALTH trial, which took place between 2012 and 2014 across five European countries. Over 700 participants aged 70 and older were divided into groups that received either placebos or omega-3, vitamin D, and exercise alone or in combination. Biological aging was measured using several DNA methylation clocks, which track changes in the body at the molecular level. The combination of omega-3, vitamin D, and exercise had the most substantial effect, slowing biological aging by up to 3.8 months over the three-year period.
Lead researcher Dr. Heike A. Bischoff-Ferrari noted that previous studies from the same trial had shown health benefits such as a reduced risk of falls and infections with omega-3 use, and an even greater reduction in pre-frailty and cancer risk when combined with vitamin D and exercise. The new findings provide a strong indication that omega-3 can slow biological aging, and when combined with vitamin D and exercise, the effects are even more pronounced. However, while the study showed promising results in slowing molecular aging, it is unclear whether this directly translates to a longer or healthier life.
Steve Horvath, Ph.D., another researcher involved in the study, emphasized that these public health strategies are affordable and safe, potentially extending health span in older adults. While the results are encouraging, some experts, like neurologist Clifford Segil, urge caution in drawing broad conclusions until further research is conducted. Segil highlighted the importance of exercise and suggested that combining supplements with exercise may someday be evidence-based, but more studies are needed to confirm the long-term benefits.
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