People with certain genes may need to workout more.
A recent study suggests that individuals struggling with obesity may face challenges influenced by their genetic makeup when attempting to shed excess weight. Researchers discovered that individuals with a higher genetic predisposition to obesity require more physical activity to prevent unhealthy weight gain.
Senior researcher Douglas Ruderfer, from the Center for Digital Genomic Medicine at Vanderbilt University Medical Center, emphasized that genetic background plays a significant role in determining the amount of physical activity needed to counteract obesity. As genetic risk increases, so does the requirement for daily steps to mitigate weight gain, regardless of established physical activity guidelines.
The study monitored over 3,100 middle-aged individuals who were not obese and maintained an average of 8,300 daily steps over five years. Findings revealed a 43% increase in obesity among those with the highest genetic risk scores, compared to a 13% increase among those with the lowest risk.
Individuals with the highest genetic risk for obesity had to walk an additional 2,280 steps per day on average to prevent weight gain compared to those with average risk. Moreover, individuals with high genetic risk and BMIs between 22 and 28 needed to increase their daily steps by 3,460 to 6,350 to match the risk level of those with the least genetic predisposition to obesity.
Lead researcher Dr. Evan Brittain noted that while it may seem intuitive that individuals with a higher genetic risk of obesity require more physical activity, this study provides quantifiable evidence of the amount needed to reduce the risk. The study, published in JAMA Network Open, suggests that individuals armed with knowledge of their genetic risk may be empowered to make healthier lifestyle choices.
Future research aims to explore whether awareness of genetic risk influences behavior and whether tailored exercise prescriptions based on genetic profiles could enhance health outcomes. Brittain envisions a future where genetic data could inform personalized physical activity recommendations, emphasizing that genetic risk does not solely determine the risk of obesity and can be mitigated through increased physical activity.
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