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FDA Greenlights First New Pain Pill In Years

Jason Phillippe by Jason Phillippe
February 2, 2025
in Health News
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FDA Greenlights First New Pain Pill In Years

Photo by Diana Polekhina on Unsplash

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It is a historic approval.

The U.S. Food and Drug Administration (FDA) has granted approval for a new pain relief medication called Journavx, which aims to provide effective pain management without the risk of addiction or overdose that is commonly associated with opioids such as Vicodin and OxyContin. Developed by Vertex Pharmaceuticals, Journavx is intended for short-term pain relief following surgeries or injuries, offering a safer alternative to both opioids and over-the-counter pain relievers like ibuprofen, according to the Associated Press.

Unlike opioids, which work by binding to receptors in the brain to alleviate pain but can lead to dependence and addiction, Journavx operates through a different mechanism. The drug blocks specific proteins that transmit pain signals to the brain, effectively preventing pain from being processed at its source. Dr. David Altshuler, Vertex’s executive vice president and chief scientific officer, highlighted that blocking pain before it reaches the brain is a critical aspect of developing non-addictive pain medications.

Clinical trials involving over 870 patients showed that Journavx provided better pain relief than a placebo after foot and abdominal surgeries, though its effectiveness was comparable to that of a common opioid-acetaminophen combination. Some experts, like Michael Schuh from the Mayo Clinic, acknowledge that while Journavx may not surpass opioids in pain relief, its unique mechanism offers significant potential as a non-addictive alternative.

However, one concern surrounding Journavx is its cost, with a price tag of $15.50 per pill, significantly higher than the $1 or less for generic opioid alternatives. Despite this, the drug’s safety profile stands out, as it does not carry the risk of addiction. Reported side effects included nausea, itching, constipation, rash, and headaches, but none of the severe risks associated with opioids, according to Dr. Charles Argoff of Albany Medical Center, who consulted with Vertex on the drug’s development.

Journavx marks a significant breakthrough in pain management, the first in over two decades, as pharmaceutical companies continue to seek solutions in response to the opioid crisis. While opioid prescriptions have decreased, the opioid epidemic persists, now largely driven by illicit fentanyl rather than prescription drugs. Despite some setbacks in trials for chronic nerve pain, Vertex remains committed to advancing Journavx’s use in chronic pain management and hopes to secure FDA approval for its broader application.

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