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Doctors Pull Off America’s First Bladder Transplant

Jason Phillippe by Jason Phillippe
May 20, 2025
in Health
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Doctors Pull Off America’s First Bladder Transplant

Photo by Piron Guillaume on Unsplash

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It’s the first-of-its-kind.

Surgeons in Southern California have made medical history by performing the first successful bladder transplant in a human patient. The operation, led by doctors from UCLA and USC, was conducted on Oscar Larrainzar, a 41-year-old man who had lost most of his bladder due to cancer. Because he also suffered from kidney failure, Larrainzar received a kidney transplant at the same time. This groundbreaking procedure is part of a limited clinical trial designed to study both the effectiveness and potential complications of bladder transplants.

Traditionally, patients without bladders undergo reconstruction using intestinal tissue. Although this method has been widely used, it often results in side effects like infections and digestive problems due to the non-sterile nature of bowel tissue. The new transplant technique offers a more natural alternative but presents its own challenges, such as the risk of organ rejection and uncertainty about whether recipients can fully regain bladder function.

Years of research and practice on animal models and donated human organs prepared the surgical team for this complex procedure. A key development in the process involved connecting the bladder’s arteries while the organ was still chilled, minimizing the number of connections needed during the transplant itself. The surgery lasted eight hours and showed immediate success, with the kidney functioning right away and Larrainzar able to urinate for the first time in years.

While the results are encouraging, medical professionals warn that this procedure won’t be right for everyone. Patients who receive organ transplants must take immunosuppressive medication for life, which can lead to serious side effects. Some doctors believe the benefits of this new method may not outweigh the risks for those who can manage with existing treatments.

Nevertheless, this successful transplant marks a major step forward in reconstructive surgery and could change how severe bladder conditions are treated in the future. As the clinical trial continues with more patients, doctors hope to gain deeper insights into the safety and potential of bladder transplantation.

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