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What Is The Medical Term For High Blood Pressure?

Jason Phillippe by Jason Phillippe
April 14, 2024
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What Is The Medical Term For High Blood Pressure?

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Experimental Drug Sparks Medical Revolution

Recent research studies, featured in The New England Journal of Medicine, scrutinized a novel medication named olezarsen, engineered to diminish levels of “bad” fat in the bloodstream known as triglycerides.

Both investigations demonstrated that olezarsen notably decreased triglyceride levels. Produced by Ionis Pharmaceuticals, olezarsen also exhibited efficacy in lowering other blood fat levels associated with disease susceptibility.

The drug stands on the brink of potential approval for individuals afflicted by a rare condition termed familial chylomicronemia syndrome, who are projected to derive the most benefit from its administration. Approximately 95% of the fats ingested by individuals constitute triglycerides, serving as a pivotal energy source. Following consumption, triglycerides eventually transit to the bloodstream.

Subsequently, they journey to muscle tissues for utilization as energy or to liver and fat cells for storage. While triglycerides play a crucial role in maintaining health, elevated levels correlate with heightened risks of heart disease and stroke.

In instances of exceptionally elevated triglyceride levels, a medical term coined hypertriglyceridemia ensues. In severe circumstances, this condition can precipitate acute pancreatitis—an abrupt inflammation of the pancreas, which in grave scenarios, can culminate in fatality.

Familial chylomicronemia syndrome represents a rare ailment characterized by escalated triglyceride levels, predisposing individuals to a heightened risk of acute pancreatitis. An estimated one in four individuals in the United States grapple with elevated triglyceride levels.

While certain individuals exhibit favorable responses to medications like statins, therapeutic options directly targeting triglycerides remain limited. Certain lifestyle modifications such as adhering to a nutritious diet, engaging in regular physical activity, and ceasing tobacco consumption can aid in lowering triglyceride levels.

Nonetheless, according to Kenneth Feingold, MD, Emeritus professor of medicine at the University of California San Francisco, individuals afflicted by familial chylomicronemia syndrome encounter formidable challenges in implementing lifestyle changes. He emphasized the necessity for adhering to an extremely low-fat diet, elucidating the arduousness of achieving satisfactory reductions in triglyceride levels solely through lifestyle modifications.

The first study enlisted 154 participants exhibiting either severe hypertriglyceridemia or moderate hypertriglyceridemia coupled with elevated cardiovascular risk. These participants received monthly olezarsen injections or a placebo. Those administered olezarsen were further subdivided into two cohorts: one receiving a 50-milligram (mg) dosage and the other an 80-mg dosage.

Relative to the placebo group, individuals receiving olezarsen demonstrated reductions in triglyceride levels by 49.3% (50 mg group) and 53.1% (80 mg group), accompanied by notable declines in other blood fat markers associated with cardiovascular risk.

In the second study, 66 individuals diagnosed with familial chylomicronemia syndrome were recruited. Segmented into three groups, participants were administered either a placebo, 50 mg of olezarsen every four weeks, or 80 mg of olezarsen every four weeks over a span of 53 weeks.

At the six-month mark, it was observed that the 80-mg dose significantly mitigated triglyceride levels, whereas the 50-mg dose did not. Importantly, a reduction in acute pancreatitis occurrences was also noted.

Upon outreach to Ionis Pharmaceuticals, it was elucidated that only one patient in the 80 mg group experienced an episode of acute pancreatitis, in contrast to 11 in the placebo group. This noteworthy revelation underscores the potential for olezarsen to emerge as the standard therapeutic approach for individuals afflicted with familial chylomicronemia syndrome.

Several experts, including Cheng-Han Chen, MD, and Gerald Watts, echoed similar sentiments regarding the research findings, highlighting the substantial efficacy of olezarsen in lowering triglyceride levels, particularly in individuals with severely elevated levels.

Although the likelihood of olezarsen’s approval for familial chylomicronemia syndrome is anticipated, further research is warranted for individuals exhibiting moderate-to-high triglyceride levels. While olezarsen may hold promise for individuals with elevated triglycerides, its primary utility is envisaged in individuals grappling with familial chylomicronemia syndrome, addressing a significant therapeutic gap for this rare disorder.

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