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New Antibodies Found To Improve Flu Vaccines

Jason Phillippe by Jason Phillippe
December 23, 2023
in Health
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New Antibodies Found To Improve Flu Vaccines

Photo by Towfiqu barbhuiya on Unsplash

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This is an amazing discovery.

For many, experiencing the flu means feeling unwell for a week or so before symptoms ease. Yet, specific groups—such as older adults, pregnant individuals, young children, and those with underlying health issues like heart disease, diabetes, or asthma—are at higher risk for severe complications due to the flu. That’s why health organizations like the Centers for Disease Control and Prevention (CDC) advocate for annual flu vaccinations, particularly among these vulnerable groups. However, recent reports indicate low vaccination rates for respiratory viruses in the U.S.

Because flu viruses mutate annually, the flu vaccine changes to match the most anticipated strains for the upcoming season. But influenza isn’t a uniform virus; it’s a diverse family with various subtypes and strains. The vaccine efficacy can vary depending on the strain, especially concerning influenza A and B types.

Recent research from the University of Pittsburgh, detailed in PLOS Biology, has spotlighted a breakthrough discovery. These scientists identified a fresh category of antibodies capable of fighting multiple subtypes of the flu virus, potentially paving the way for a broader-spectrum flu vaccine. Dr. Kevin McCarthy, from the Center for Vaccine Research at the University of Pittsburgh, explained that while antibodies offer strong protection against the flu, the virus evolves to evade them, necessitating updated vaccines.

Their study revealed that certain antibodies can neutralize specific H1 and H3 flu strains, even if the virus mutates its hemagglutinin protein. These findings suggest that some individuals produce antibodies that can combat multiple flu subtypes, offering hope for improved vaccine design and testing.

Additionally, Dr. McCarthy highlighted concerns about vaccine production processes, such as using eggs, which might alter antibodies’ intended targets. Transitioning away from egg-based vaccines could minimize these issues, as alternatives exist.

Dr. David Cutler, a family medicine physician, emphasized the potential impact of these discoveries. He noted that while diseases like smallpox or polio have been controlled or eradicated due to vaccines, influenza remains a significant threat, causing thousands of deaths yearly in the U.S. The newly identified antibodies, which target less variable sites on the virus, could potentially offer broader protection against various flu strains, presenting promising possibilities for flu prevention.

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