Scientists have recently found that mice with diabetes that received treatment with a vitamin A analog had significantly improved eyesight.
New research has shown that a single dose of the chromophore 9-cis-retinal, an analog of vitamin A, can significantly improve reduced visual function in mice with diabetes.
According to the National Eye Institute, diabetic retinopathy is an eye condition that can result in the loss of vision for people with diabetes.
In its mid to late stages, the condition occurs due to damage to the blood vessels in a person’s retina.
People with diabetes are at risk of having too much sugar in their blood. The sugar can cause blood vessels to block, resulting in bleeding. The eye can develop new blood vessels, but these typically do not function well and can also easily bleed.
Vitamin A is crucial for the normal functioning of vision. According to the Office of Dietary Supplements, it helps in the development of a protein that enables the retina to absorb light, which is linked to the chromophore 11-cis-retinal the eye needs to continually produce for optimum vision.
The authors of the new study note that there is evidence to suggest that diabetes can lead to deficiencies in vitamin A, and that 11-cis-retinal is lower in rats with diabetes.
The study authors found that the mice that received treatment with 9-cis-retinal had significantly improved vision across all measures.
According to Dr. Moiseyev, “This work supports our novel hypothesis that diabetes-induced disturbance of the vitamin A metabolism in the eye is responsible for reduced visual function in early stages of diabetic retinopathy.”
“Currently, there is no available therapy to prevent the development of the retinal complication in [people with] diabetes.”
“This study suggests that the delivery of visual chromophore to the diabetic eye may represent a potential therapeutic strategy for the early stages of diabetic retinopathy to prevent vision loss in [people] with diabetes.”Dr. Gennadiy Moiseyev
Medical reference: Medical News Today